| Abstrakt: |
In hypothyroid rats, partial hepatectomy does not induce liver regeneration until 120 h aftersurgical operation, when, instead, in normal rats a complete recovery of the liver mass, in thisinterval, is observed. In normal rats, a good efficiency of mitochondrial oxidative phosphorylationis needed as an energy source for liver regeneration (Guerrieri, F. et al., 1995); inhypothyroid rats the efficiency of mitochondrial oxidative phosphorylation is low in the 0–120h interval after partial hepatectomy. This low efficiency of oxidative phosphorylation appearsto be related to a low mitochondrial content of F0F1-ATP synthase, in liver of hypothyroidrats, which does not recover after partial hepatectomy. In the liver of hypothyroid rats, lowlevels of the nuclear-encoded mitochondrial catalytic βF1 subunit and of its transcript areobserved and they do not increase, as occurs in normal rats, after partial hepatectomy. [ABSTRACT FROM AUTHOR] |
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