The association between IgG1, IgG2 subclasses toward human papillomavirus 16-like particles in the serum and cervical intraepithelial neoplasia.

Autor: Han, Ling, Zhang, Bingyi, Li, Hairong, Zuo, Manzhen, Xue, Yuezhen, Zhang, Jun
Zdroj: Chinese-German Journal of Clinical Oncology; May2010, Vol. 9 Issue 5, p278-282, 5p
Abstrakt: The paper aimed to study the relationship between the expressions of immunoglobulin G (IgG) subclasses toward human papillomavirus 16-like particles (HPV16VLPs) in the serum of patients and different grades of cervical lesions. The expressions of IgG subclasses in 32 cases of human papillomavirus (HPV) infection, 30 cervical intraepithelial neoplasia (CIN I), 43 CIN II–III, and 24 hysteromyoma and chronic cervicitis were examined by ELISA. The absorbance values of HPV16VLPs-IgG, IgG1 increased with the grade of CIN ( P < 0.05). The IgG2 dominance (IgG2/IgG1 ratio > 1) from control group was 100%, 87.50% for HPV infection group, 75% for CIN I group, compared with that from CIN II–III patients (9.52%) ( P < 0.05). The positive rates and absorbance values of HPV16VLPs-IgG, IgG1 and IgG2 from HPV16-DNA positive group were significantly higher than those from non-HPV16-DNA positive group ( P < 0.05). There was a moderate correlation between the HPV16-DNA testing and detection of HPV16VLPs-IgG ( r = 0.531, P < 0.05). An increase of the expressions of HPV16VLPs-IgG and its subclasses in the serum of the patients with cervical precancerous lesions, especially those with CIN II–III, might be associated with duration of HPV infection and severity of cervical lesions. An increase of the IgG2 dominance (IgG2/IgG1 > 1) in serum from low grade cervical lesions group and normal control group, might indicate the clearance of HPV infection and the regression of cervical lesions. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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