| Autor: |
Bello, Iraldo, Perez, Anaiza, Torres, Ana, Hernández, Maria, López Saura, Pedro |
| Zdroj: |
Biotherapy; Mar1998, Vol. 11 Issue 1, p53-57, 5p |
| Abstrakt: |
Soluble receptors for hormones and cytokines have beendescribed. They can serve as natural blockers of theirrespective ligands. The natural soluble interferongamma receptor (sIFNγR) has been isolated andcharacterized only in urine. Chromatography of human(hu) plasma from rheumatoid arthritis (RA) patientsand controls on immobilized hu IFN γ orantibodies against IFN γ R α chainpermitted us to isolate the sIFNγR. Thereceptor isolated from one control is a protein witha molecular weight between 60-67 kDa depending on thepresence of reducing agents. We detected asignificantly higher level of plasma sIFNγR inpatients with rheumatoid arthritis than in apparentlyhealthy subjects. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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