| Autor: |
Hayashi, Kayo, Ohta, Yuji, Kumano, Kazuo, Horiuchi, Takashi |
| Zdroj: |
Journal of Artificial Organs; Sep1998, Vol. 1 Issue 2, p76-79, 4p |
| Abstrakt: |
A relation between the mass transfer area coefficient (MTAC) and development of chemically induced fibrosis was evaluated. 20ml/kg of 0.08–0.2wt% chlorhexidine gluconate (CHG) was injected into the abdominal space of male Wistar rats (at 8 weeks). After 1–2h dwell, CHG was discarded and then the abdominal space was flushed with 20ml/kg of 0.9% saline solution three times. A peritoneal equilibration test (PET) was carried out every week for 1 month using Lactate Ringer solution containing 100 mg/dl of urea-N, 10 mg/dl of creatinine, and 1.5% of albumin. Eight out of 11 rats survived, 5 out of 8 rats developed adhesions, and 1 developed sclerosing encapsulating peritonitis-like degeneration. Although there was no statistically significant change in MTAC, MTAC increased from 1.18±0.66 ml/min to 1.92±0.6 ml/min in the first 3 weeks ( P=0.09), and slightly decreased at the fourth week. It can be concluded that increase of MTAC may be due to increase of peritoneal permeability and/or increase of effective surface area such as angiogenesis. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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