| Autor: |
Fernández-Arcás, N, Dieguez-Lucena, JL, Muñoz-Morán, E, Ruiz-Galdón, M, Espinosa-Caliani, S, Aranda-Lara, P, Rius-Diaz, F, Gaitán-Arroyo, MJ, De Teresa-Galván, E, Reyes-Engel, A |
| Předmět: |
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| Zdroj: |
Clinical Genetics; Jul2001, Vol. 60 Issue 1, p52-57, 6p |
| Abstrakt: |
We have studied the role of three polymorphic genes of the renin-angiotensin system (RAS) as independent risk factors for myocardial infarction (MI) and their correlation with three of the major coronary risk factors: serum cholesterol (CH), hypertension (HT) and smoking (SM). A population of 392 men was genotyped for the M235T polymorphism of the angiotensinogen (AGT) gene, the insertion/deletion of the angiotensin-converting enzyme (ACE) and the all66c of the angiotensin-II type 1 receptor (AT1R), by means of polymerase chain reaction (PCR) and restriction enzyme analysis. It was observed that the T allele frequency increased significantly in the MI with HT, CH, and SM subgroup (0.58 vs 0.31) (p<0.01). In contrast, the M allele frequency was higher in the MI without HT, CH, and SM (0.69 vs 0.42) (p<0.01). A strong association between the MM genotype and MI (p<0.001, odds ratio=4.29, confidence interval=1.95–9.42) was found when age-matched MM control subjects were compared to MI individuals with none of the other known major coronary risk factors. Futhermore, subjects with the MM genotype showed a significantly higher plasma renin activity (PRA) profile than those with the TT genotype (p<0.001). It can be concluded that the M allele is an independent risk factor for MI and the T allele modified the risk when other major risk factors are present. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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