Alcohol and risk of breast cancer in Mexican women.

Autor: Beasley, Jeannette, Coronado, Gloria, Livaudais, Jennifer, Angeles-Llerenas, Angélica, Ortega-Olvera, Carolina, Romieu, Isabelle, Lazcano-Ponce, Eduardo, Torres-Mejía, Gabriela, Beasley, Jeannette M, Coronado, Gloria D, Angeles-Llerenas, Angélica, Torres-Mejía, Gabriela
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Zdroj: Cancer Causes & Control; Jun2010, Vol. 21 Issue 6, p863-870, 8p, 3 Charts
Abstrakt: Background: Little is known about the relationship between alcohol intake and breast cancer risk among Mexican women. This association may be modified by folate and Vitamin B12.Methods: A population-based case-control study conducted in Mexico recruited 1,000 incident breast cancer cases aged 35-69 and 1,074 controls matched on age, region, and health care system. In-person interviews were conducted to assess breast cancer risk factors and recent diet using a food frequency questionnaire. Conditional logistic regression models estimated adjusted odds ratios and 95% confidence intervals.Results: Over one-half (57%) of cases and less than one-half of controls (45%) reported any lifetime alcohol consumption. Compared with never drinkers, women reporting ever drinking (Adjusted OR = 1.25, 95% CI = 0.99-1.58) had a greater odds of breast cancer. There was evidence for interaction in the association between ever consuming any alcohol and breast cancer by folate (p for interaction = 0.04) suggesting women with lower folate intake had a higher odds of breast cancer (Adjusted OR = 1.99, 95% CI = 1.26-3.16) compared to women with higher folate intake (OR = 1.12, 95% CI = 0.69-1.83).Conclusions: Our findings support evidence that any alcohol intake increases risk of breast cancer. Insufficient intake of folate may further elevate risk for developing breast cancer among women who consume alcohol. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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