| Autor: |
Bui, Chinh, Bray, Andrew, Pham, Yen, Campbell, Rhonda, Ercole, Francesca, Rasoul, Firas, Joe Maeji, N. |
| Zdroj: |
Molecular Diversity; Sep1998, Vol. 4 Issue 3, p155-163, 9p |
| Abstrakt: |
The 5-(4-formyl-3,5-dimethoxyphenoxy)valeric acid (Barany)linker and its monomethoxy analog were applied to theMultipin™ method of solid phase synthesis. Acomparative assessment of reductive amination and cleavage ofthese linkers under conditions of multiple synthesis indicatedthat both were applicable to a broad range of primary aminesincluding aniline and 4-nitroaniline. Apart from the greaterlability of the dimethoxy version under TFA cleavage, there wasno observable advantage of one linker over the other within thedescribed experiment. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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