| Autor: |
Sanders, Melissa E., Moore III, Quincy C., Norcross, Erin W., Shafiee, Afshin, Marquart, Mary E. |
| Předmět: |
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| Zdroj: |
Journal of Ocular Pharmacology & Therapeutics; Apr2010, Vol. 26 Issue 2, p193-198, 6p |
| Abstrakt: |
Purpose: To determine the effectiveness of topically applied besifloxacin, gatifloxacin, and moxifloxacin for the early treatment of experimental methicillin-resistant Staphylococcus aureus (MRSA) keratitis. Methods: Ten hours post-MRSA infection, rabbit eyes were treated topically with 19 doses of phosphate-buffered saline (PBS), besifloxacin, gatifloxacin, or moxifloxacin. Slit-lamp examinations were performed before and after the inoculation. Corneas were harvested for bacterial quantitation and minimal inhibitory concentrations (MICs) were determined. Results: All 3 fluoroquinolones significantly lowered the clinical severity of the infection as compared to treatment with PBS ( P < 0.05). However, the mean log10 colony-forming unit (CFU) recovered from besifloxacin-treated corneas was significantly lower than all other treatment groups ( P < 0.01). CFU recovered from corneas treated with moxifloxacin and PBS showed no significant difference ( P = 0.12). Corneas treated with gatifloxacin had a significantly lower log10 CFU recovered as compared to PBS-treated corneas ( P < 0.01). The MICs for gatifloxacin and moxifloxacin were 8 μg/mL, whereas the MIC for besifloxacin was 1 μg/mL. Conclusions: All 3 fluoroquinolones significantly lowered the clinical severity of the infection. Besifloxacin had an 8-fold lower MIC for MRSA than gatifloxacin and moxifloxacin, and was significantly more effective than gatifloxacin and moxifloxacin in reducing the number of MRSA in the rabbit cornea. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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