| Autor: |
Yazawa, Kazuyuki, Fujimori, Minoru, Nakamura, Toshiyuki, Sasaki, Takayuki, Amano, Jun, Kano, Yasunobu, Taniguchi, Shun’ichiro |
| Zdroj: |
Breast Cancer Research & Treatment; Mar2001, Vol. 66 Issue 2, p165-170, 6p |
| Abstrakt: |
A fundamental obstacle in cancer gene therapy is the specific targeting of therapy directly to a solid tumor, and no systemic delivery system yet exists. A strain of domestic bacteria, Bifidobacteriumlongum, which is nonpathogenic and anaerobic, selectively localized to and proliferated in 7,12 dimethylbenz[a]anthracene induced rat mammary tumors after systemic application. We further ascertained the tumor specificity of genetically engineered, as well as wild type, Bifidobacterium longum. This is the first demonstration that Bifidobacterium longum can be utilized as a specific gene delivery vector for gene therapy on solid breast tumors. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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