| Autor: |
Watanabe, Kenshi, Kikuchi, Kenji, Ichikawa, Naoya, Ando, Yuichi, Meigata, Kazuhiko, Nishimura, Yoji, Nomura, Yuji, Degawa, Toshikazu, Beck, Yoshifumi, Tomikawa, Shinji, Nagao, Takeshi, Uchida, Hisanori |
| Zdroj: |
Surgery Today; Dec1997, Vol. 27 Issue 12, p1160-1166, 7p |
| Abstrakt: |
The aim of this study was to examine the immunosuppressive effect of bactobolamine (BBL) alone and in combination with tacrolimus (FK) using in vitro proliferation assays on human peripheral blood lymphocytes (PBLs) and in vivo liver allografts in rats. In the latter setting, the immunosuppressive activity of BBL alone and in combination with FK was compared to that of mizoribine (MIZ). The interactions between BBL and FK and between MIZ and FK were assessed by the combination index (CI) proposed by Chou and Kahan. In the in vitro study, the combination of BBL and FK displayed stronger inhibitory effects on T-cell proliferation than when each drug was applied alone. The mean CI values for the BBL/FK combination were below 1.0, rangin from 0.19 to 0.86, indicating synergism between BBL and FK. In the in vivo study, 50–200 mg/kg/day BBL monotherapy significantly prolonged survival compared with a control group, and the effect was dose-dependent. Conversely, the efficacy of MIZ monotherapy at 2.5–10 mg/kg/day did not increase dose-dependently. The CIs for MIZ at doses of 2.5 and 5.0 mg/kg/day with FK 0.08 mg/kg/day were 0.48 and 0.42, respectively, indicating therapeutic synergism between MIZ and FK. The CI for BBL 100mg/kg/day with FK was 0.26, which indicated further synergism between BBL and FK. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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