| Autor: |
Voors, Adriaan A., Van De Wal, Ruud M., Hartog, Jasper W. L., Vijn, Richard G., Hummel, Yoran M., Plokker, Thijs W. M., Van Veldhuisen, Dirk J., Jaarsma, Wybren |
| Zdroj: |
Cardiovascular Drugs & Therapy; Feb2010, Vol. 24 Issue 1, p33-40, 8p, 4 Charts, 3 Graphs |
| Abstrakt: |
To compare the effects of an angiotensin receptor blocker(ARB)-based regimen versus a non-ARB based regimen on diastolic function and neurohormones in patients with hypertension and diastolic dysfunction. 97 patients with a systolic blood pressure (SBP) ≥140 mmHg, a left ventricular ejection fraction >0.50, and echocardiographic evidence of diastolic dysfunction were randomly assignment to open-label treatment with eprosartan (with other anti-hypertensives; n = 47) or other anti-hypertensives alone ( n = 50). Echocardiography, including tissue Doppler imaging (TDI), and neurohormones were done at baseline and after 6 months. Mean age was 65 (±10) years and 64% was female. During 6 months of treatment, SBP decreased from 157 ± 16 to 145 ± 18 mmHg in the eprosartan group and from 158 ± 17 to 141 ± 18 mmHg in the control group (both p < 0.001; p = ns between groups). Diastolic function was unaffected in both groups and there was no correlation between changes in SBP and changes in mean TDI ( r = −0.06; p = 0.58). Aldosterone levels decreased in the eprosartan group, but other neurohormones remained largely unchanged. Change in SBP was however related to the change in NT-proBNP ( r = 0.26; p = 0.019). Lowering blood pressure, either with eprosartan or other anti-hypertensives in hypertensive patients with diastolic dysfunction did not change diastolic function after 6 months of treatment, but was associated with a decrease of NT-proBNP. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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