Isolation of ergosterol peroxide and its reversion to ergosterol in the pathogenic fungus Sporothrix schenckii.

Autor: da Graça Sgarbi, Diana, da Silva, Antonio, Carlos, Iracilda, Silva, Célio, Angluster, Jayme, Alviano, Celuta
Zdroj: Mycopathologia; Jul1997, Vol. 139 Issue 1, p9-14, 6p
Abstrakt: Ergosterol peroxide, a presumed product of the H_2O_2-dependent enzymatic oxidation of ergosterol, has been isolated from yeast forms of the pathogenic fungus Sporothrix schenckii. The substance, which may have a role in fungal virulence, has been characterized mainly using spectroscopic methods (1H and 13C nuclear magnetic resonance and high resolution mass spectra). The purified compound showed a molecular formula of C_28H_44O_3, displaying characteristic features of epidioxy sterols and was reverted to ergosterol when submitted to S. schenckii enzymatic extract. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index