Inhibition of TNFα-induced cyclooxygenase-2 expression by amentoflavone through suppression of NF-κB activation in A549 cells.

Autor: Banerjee, Tinku, Valacchi, Giuseppe, Ziboh, Vincent, van der Vliet, Albert
Zdroj: Molecular & Cellular Biochemistry; Sep2002, Vol. 238 Issue 1/2, p105-110, 6p
Abstrakt: Amentoflavone, a biflavonoid with antiinflammatory activity, downregulates COX-2 expression in TNFα-activated A549 cells with concomitant inhibition of NF-κB mediated signaling cascades. We demonstrate here that amentoflavone inhibits NF-κB/DNA binding activity potently along with inhibition of degradation of IκBα and NF-κB translocation into nucleus in TNFα-activated A549 cells. This flavonoid upregulates PPAR γ, a transcription factor involved in repressing many cytokine-induced gene expressions. Hence amentoflavone, a dietary constituent, may be of therapeutic value for several lung diseases where COX-2 plays an important role. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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