| Autor: |
Mizumatsu, Shinichiro, Matsumoto, Kengo, Ono, Yasuhiro, Tamiya, Takashi, Furuta, Tomohisa, Ohmoto, Takashi |
| Zdroj: |
Journal of Neuro-Oncology; Aug2000, Vol. 49 Issue 1, p41-47, 7p |
| Abstrakt: |
We examined whether the intrathecal MX2 chemotherapy for treating dissemination of malignant glioma would be a feasible therapy. In the toxicity study, physiological and histological neurotoxicity was not observed in the rats treated with less than 100 μg/kg of MX2 administered intracisternally. But physiological side effects were observed in the treatment group of more than 200 μg/kg and histological brain toxicity was in the treatment group of more than 1000 μg/kg. Dissemination models were induced in rats by intracisternal inoculation of C6 glioma cells. The median survival times of the rats treated with 100 μg/kg of intrathecal MX2 on day 1, 3, or 7 after tumor inoculation were prolonged by 52.4% ( p=0.0006), 31.5% ( p=0.0007), and 7.1% ( p=0.0180), respectively, compared to that of untreated control animals. Intrathecal MX2 treatment also cured 33.6% of rats in the treatment group. These findings suggested that there was a possibility that intrathecal MX2 would be a safe and effective method for treating dissemination of malignant glioma. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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