| Autor: |
Cucurull, E., Espinoza, L.R., Mendez, E., Molina, J.F., Molina, J., Ordi-Ros, J., Gharavi, A.E. |
| Předmět: |
|
| Zdroj: |
Lupus; 1999, Vol. 8 Issue 2, p134-141, 8p |
| Abstrakt: |
We studied the prevalence, isotype distribution, and clinical significance of anticardiolipin (aCL) and anti-β[sub 2]glycoprotein I (anti-β[sub 2]GPI) antibodies in two populations of patients with systemic lupus erythematosus (SLE), 160 Colombians and 160 Spaniards. All sera were tested in our laboratory by enzyme-linked immunosorbent assay (ELISA) for IgG, IgM, and IgA aCL, as well as IgG and IgM anti-β[sub 2]GPI. Positive results for at least 1 of the 3 aCL isotypes were found in 40 Colombians (25%) and 55 Spaniards (34%). IgG aCL was the predominant isotype in both populations. Positive results for at least 1 of the anti-β[sub 2]GPI isotypes were found in 34 Colombians (21%) and 29 Spaniards (18%). IgG anti-β[sub 2]GPI was the dominant isotype in Colombians, while IgM was predominant in Spaniards. Positivity for anti-β[sub 2]GPI in aCL-positive patients was present in 77% in the Colombian group and 50% in the Spaniard group. Among Colombians, IgG aCL and anti-β[sub 2]GPI correlated with thrombosis, fetal loss, and thrombocytopenia. Among Spaniards, IgG aCL and IgG anti-β[sub 2]GPI correlated with thrombosis, fetal loss, and livedo reticularis. For detecting thrombosis and fetal loss, aCL ELISA was more sensitive than anti-β[sub 2]GPI in Spaniards, and anti-β[sub 2]GPI ELISA was more specific than aCL in both populations. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
