| Autor: |
Rapado, A., Hawkins, F., Sobrinho, L., Díaz-Curiel, M., Galvao-Telles, A., Arver, S., Melo Gomes, J., Mazer, N., Garcia e Costa, J., Horcajada, C., López-Gavilanes, E., Mascarenhas, M., Papapietro, K., López Álvarez, Ma B., Pereira, Ma C., Martinez, G., Valverde, I., García, J. J., Carballal, J. J., García, I. |
| Zdroj: |
Calcified Tissue International; Dec1999, Vol. 65 Issue 6, p417-421, 5p |
| Abstrakt: |
To clarify the relationship of sex male hormones and bone in men, we studied in 140 healthy elderly men (aged 55-90 years) the relation between serum levels of androgens and related sex hormones, bone mineral density (BMD) at different sites, and other parameters related to bone metabolism. Our results show a slight decrease of serum-free testosterone with age, with an increase of follicle stimulating hormone (FSH) and luteinizing hormone (LH) in a third of the elderly subjects studied. BMD decreased significantly with age in all regions studied, except in the lumbar spine. We found a positive correlation between body mass index (BMI) and BMD at the lumbar spine and femoral neck (P < 0.001). No relationship was found (uni- and multivariate regression analysis) between serum androgens or sex hormone-binding globulin (SHBG) and BMD. We found a positive correlation of vitamin D binding protein (DBP) and osteocalcin with lumbar spine BMD and with BMI, DBP, IGF-1, and PTH with femoral neck BMD. In conclusion, there is a slight decline in free testosterone and BMD in the healthy elderly males. However, sex male hormones are not correlated to the decrease in hip BMD. Other age-related factors must be associated with bone loss in elderly males. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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