| Autor: |
Hiroi-Furuya, E., Kameda, T., Hiura, K., Mano, H., Miyazawa, K., Nakamaru, Y., Watanabe-Mano, M., Okuda, N., Shimada, J., Yamamoto, Y., Hakeda, Y., Kumegawa, M. |
| Zdroj: |
Calcified Tissue International; Mar1999, Vol. 64 Issue 3, p219-223, 5p |
| Abstrakt: |
Bisphosphonates, therapeutic reagents against tumoral bone diseases (Paget's disease or osteoporosis), are potent inhibitors of bone resorption. The mechanisms by which they directly act on mature osteoclasts remain unclear. Using a recently developed technique for isolation of highly purified mammalian mature osteoclasts, we demonstrated that etidronate [ethane-1-hydroxy-1,1-diphosphonate (EHDP), 1-hydroxy-1,1-ethylidenebisphosphonate], inhibited directly osteoclastic bone-resorbing activity by pit assay. In addition, EHDP also directly induced apoptosis and disrupted actin rings in osteoclasts. The data support previous data on non-purified osteoclasts and results in vivo. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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