| Autor: |
Figgs, Larry, Holland, Nina, Rothman, Nathanial, Zahm, Shelia, Tarone, Robert, Hill, Robert, Vogt, Robert, Smith, Martyn, Boysen, Cathy, Holmes, Frederick, VanDyck, Karen, Blair, Aaron, Figgs, L W, Holland, N T, Rothmann, N, Zahm, S H, Tarone, R E, Hill, R, Vogt, R F, Smith, M T |
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| Zdroj: |
Cancer Causes & Control; Apr2000, Vol. 11 Issue 4, p373-380, 8p |
| Abstrakt: |
Objective: Evaluate peripheral blood lymphocyte proliferation (replicative index:RI) and micronuclei frequency (MF) among 2,4-D herbicide applicators.Methods: Twelve applicators spraying only 2,4-D provided a blood and urine specimen upon enrollment, several urine samples during the spraying season, and a blood specimen at the study's end. Nine controls provided blood and urine specimens upon enrollment and at the study's end. Gas chromatography/tandem mass spectroscopy determined urinary 2,4-D levels and standard in-vitro assays determined RI and MF scores. Applicator RI and MF were compared before and after spraying and with controls.Results: Applicators contributed 45 urine specimens with concentrations ranging from 1.0 to 1700 (microg 2,4-D/g creatinine/L urine) that logarithmically (In) increased as spraying time increased. Applicator RI increased after spraying (p = 0.016), independent of tobacco and alcohol use, and demonstrated a weak dose-response with increasing urinary 2,4-D levels (p = 0.15). Among 2,4-D applicators, pre-exposure complete blood counts and lymphocyte immunophenotypes were not significantly different from post-exposure measurements.Conclusion: Urinary 2,4-D concentration, an exposure biomarker, may be associated with lymphocyte replicative index, a cell proliferation biomarker. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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