Cigarette smoking and breast cancer risk among young women (United States).

Autor: Gammon, Marilie, Schoenberg, Janet, Teitelbaum, Susan, Brinton, Louise, Potischman, Nancy, Swanson, Christine, Brogan, Donna, Coates, Ralph, Malone, Kathleen, Stanford, Janet, Gammon, M D, Schoenberg, J B, Teitelbaum, S L, Brinton, L A, Potischman, N, Swanson, C A, Brogan, D J, Coates, R J, Malone, K E, Stanford, J L
Zdroj: Cancer Causes & Control; Dec1998, Vol. 9 Issue 6, p583-590, 8p
Abstrakt: Objectives: To evaluate whether heavy cigarette smoking as a teenager or long-term smoking increases breast cancer risk or, alternatively, whether smoking acts as an anti-estrogen and reduces risk.Methods: Data from a multi-center, population-based, case-control study among women under age 55 were analyzed.Results: Among women under age 45, there was a modest inverse relation with current (OR = 0.82, 95% CI = 0.67, 1.01) but not past (OR = 0.99, 95% CI = 0.81, 1.21) smoking. Odds ratios were decreased for current smokers who began at an early age (0.59 for < or = 15, 95% CI = 0.41, 0.85) or continued for long periods of time (0.70 for >21 years, 95% CI = 0.52, 0.94). In subgroup analyses, reduced odds ratios were observed among current smokers who were ever users of oral contraceptives (0.79, 95% CI = 0.63, 0.98), were in the lowest quartile of adult body size (0.53, 95% CI = 0.34, 0.81), or never or infrequently drank alcohol (0.68, 95% CI = 0.47, 0.98). Among women ages 45-54, there was little evidence for an association with smoking.Conclusions: These results suggest that breast cancer risk among women under age 45 may be reduced among current smokers who began smoking at an early age, or long-term smokers, but require confirmation from other studies. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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