Simultaneous occurrence of a supra- and an infratentorial glioma in a patient with Ollier's disease: more evidence for non-mesodermal tumor predisposition in multiple enchondromatosis.

Autor: Hofman, Steven, Heeg, Minne, Klein, Jan-Paul, Krikke, Allard P., Hofman, S, Heeg, M, Klein, J P, Krikke, A P
Zdroj: Skeletal Radiology; Dec1998, Vol. 27 Issue 12, p688-691, 4p
Abstrakt: A case is presented in which two neuro-ectodermal tumors, an infra- and a supratentorial glioma, developed in a young man with multiple enchondromatosis of Ollier's disease. This is the third such case of multifocal low-grade glioma in Ollier's disease, suggesting a predisposition for non-mesodermal tumors in Ollier's disease. The related condition of multiple enchondromatosis and hemangiomas (Maffucci's syndrome) is well known for its malignant potential, developing both mesodermal and non-mesodermal tumors. Along with other authors, we support the concept of two variants of the same disease with a predisposition to development of tumors from various germ layers. [ABSTRACT FROM AUTHOR]
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