| Autor: |
Toyota, Nobuhiko, Katano, Kuniyuki, Takahashi, Sadamu, Ohtani, Shinji, Mizusawa, Kiyoaki, Hamazoe, Ryuichi, Kaibara, Nobuaki |
| Zdroj: |
Surgery Today; May1997, Vol. 27 Issue 5, p414-419, 6p |
| Abstrakt: |
The biological malignancy of pancreatic carcinoma was evaluated by determining the score of the argyrophilic nucleolar organizer region (Ag-NOR) in resected specimens, and comparing it with the various clinicopathological factors and long-term results of 38 patients who underwent surgical resection for invasive ductal carcinoma of the pancreas between 1977 and 1992, in whom the Ag-NOR could be stained. The Ag-NOR analysis of pancreatic carcinomas from the 38 patients resulted in a mean Ag-NOR score of 3.82±0.62, which was significantly ( P<0.01) higher than the mean score of 1.72±0.28 observed in normal pancreatic tissues obtained from 20 of these patients. The mean Ag-NOR score significantly increased in patients with anterior capsular infiltration (s) ( P<0.01), posterior tissue infiltration (rp) ( P<0.01), and lymph node metastasis (n) ( P<0.05) compared to those without these factors. The rate of curability A or B was only 13.0% in patients with a high Ag-NOR score of ≧3.80 in comparison to 66.7% in those with a low Ag-NOR score of <3.80. The 3-year survival rate was significantly ( P<0.05) higher in the low Ag-NOR score group than in the high Ag-NOR score group. These results suggest that the Ag-NOR score can serve as an indicator of the biological malignancy of pancreatic carcinoma, and of the patients' prognosis. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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