Trypanosoma cruzi : IgG1 and IgG2b are the main immunoglobulins produced by vaccinated mice.

Autor:	Pyrrho, Alexandre S., Moraes, Jorge L. C., Peçanha, Lígia M. T., Gattass, Cerli R.
Zdroj:	Parasitology Research; Mar1998, Vol. 84 Issue 4, p333-337, 5p
Abstrakt:	Mice vaccinated with CL-14, a non-infective and non-pathogenic clone isolated from Trypanosoma cruzi CL strain, become protected against lethal challenge by infective trypomastigotes. It has been shown that animals infected with T. cruzi show polyclonal activation of B lymphocytes with an early production of several non-specific immunoglobulins. Vaccinated mice, however, have an early production of antigen-specific IgG1 and IgG2b. Considering the lack of infectivity of CL-14, our data strongly suggest a role for IgG1 and IgG2b in protection to T. cruzi. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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