| Autor: |
Knott, I., Weynants, V., Walravens, K., van der Poel, W. H. M., Kramps, J. A., Letesson, J. J. |
| Zdroj: |
Archives of Virology; Jun1998, Vol. 143 Issue 6, p1119-1128, 10p |
| Abstrakt: |
The immune response of calves was studied following infection with non-cell-passaged Bovine respiratory syncytial virus (BRSV). Two groups of 6 specific pathogen free (SPF) calves were housed in separate isolation rooms. One group was inoculated intranasally with a non-cell-passaged BRSV strain and the control group was mock-infected. A BRSV specific antibody response was observed for all the BRSV infected calves. These antibodies were shown to have neutralizing activity. No lymphocyte proliferation response was detected in the mock-infected group whereas three animals in the infected group were positive three weeks after the infection. All BRSV-infected calves, except one, produced interferon-γ (IFN-γ) one week post-infection and IFN-γ was observed in all six infected calves after three weeks. The control group showed no IFN-γ synthesis. In spite of the limits of the BRSV infection model, humoral and cellular immune responses were actively developed by all the calves against this pathogen. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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