Soluble intercellular adhesion molecule-1 in sera from patients with chronic hepatitis C undergoing interferon treatment.

Autor: Sonnante, A. M., Cozzolongo, R., Cuppone, R., Michele, G. De, Manghisi, O. G., Quaranta, M.
Zdroj: Archives of Virology; Mar1997, Vol. 142 Issue 3, p567-569, 3p
Abstrakt: To study the influence of interferon therapy on soluble intercellular adhesion molecule-1 we measured sICAM-1 levels in 22 patients with type C chronic hepatitis treated with interferon. We also studied 9 healthy subjects as control group. The results showed statistically significant higher levels of sICAM-1 in patients with liver disease than in the controls. The sICAM-1 baseline levels were similar in patients with chronic active hepatitis or cirrhosis but, during therapy, these levels decreased only in patients with chronic hepatitis. After IFN withdrawal sICAM-1 levels rebounded to initial values. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index