Systems Approach to Optimization of the Regimen of Photodynamic Therapy of Solid Sarcoma M-1 Using the “Fotosens” Preparation as Example.

Autor: Lagoda, T., Kaplan, M., Krivosheev, Ya., Zhavoronkov, L., Taraban, V., Bokova, M., Bondar', A., Posadskaya, V.
Zdroj: Journal of Russian Laser Research; Nov2001, Vol. 22 Issue 6, p488-504, 17p
Abstrakt: A systems analysis of the interaction between objects (tumor, healthy tissue, radiation, and photosensitizer of the singlet state of oxygen) involved in photodynamic therapy was carried out. A schematic diagram of the biologically significative processes proceeding under these circumstances was proposed. This schematic diagram can serve as a basis for a systems approach to the optimization of photodynamic therapy. The efficiency of the systems approach in photodynamic therapy was demonstrated using “Fotosens” and “Khlorin S” preparations, β carotene, and dodecaprene β -carotene in biological experiments on Wistar rats and mouses inoculated for the solid sarcoma M-1. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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