| Autor: |
Falameeva, O., Poteryaeva, O., Zhanaeva, S., Levina, O., Filatova, T., Korolenko, T., Kaledin, V., Sandula, I., Kogan, G. |
| Zdroj: |
Bulletin of Experimental Biology & Medicine; Aug2001, Vol. 132 Issue 2, p787-790, 4p |
| Abstrakt: |
We studied the effect of macrophage stimulator water-soluble β-(1→3)-D-carboxymethylglucan on the efficiency of cyclophosphamide chemotherapy in Lewis lung carcinoma. Cyclophosphamide inhibited the growth of primary tumor nodes by 57%. The preparation possessed pronounced antimetastatic activity: metastases were found in 40.9% animals. Combination therapy with cyclophosphamide and (1→3)-beta;-D-glucan inhibited the growth of intramuscular tumors by 75-89% and reduced the incidence of metastases into the lungs by 92-94%. The therapeutic effect was most pronounced after simultaneous administration of these preparations: tumor growth was suppressed by 89.3% and metastases were found in only 7.5% animals (vs. 100% in the control). The potentiating effect of β-(1→3)-D-carboxymethylglucan is related to accumulation of cysteine proteinase inhibitors in the tumor tissue and plasma, but not to changes in blood cell composition. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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