Genetic heterogeneity of heat shock protein synthesis and sensitivity of mouse splenocytes to antiproliferative effect of alkylating agents.

Autor: Pukhal'skii, A., Vikulova, V., Toptygina, A., Lyashko, V.
Zdroj: Bulletin of Experimental Biology & Medicine; Nov1997, Vol. 124 Issue 5, p1118-1122, 5p
Abstrakt: The intensity of heat shock protein synthesis by splenocytes is assessed in mice of two strains with genetically different sensitivity to antiproliferative effect of alkylating effect of maphosphamide. The content and de novo production of heat shock proteins in resistant BALB/c mice are higher than in sensitive DBA/2 mice. Exposure to heat shock increases cell resistance to antiproliferative action of maphosphamide. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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