Microbiological transformation of piperidine and pyridine derivatives.

Autor: Modyanova, L., Duduchava, M., Piskunkova, N., Grishina, G., Terent'ev, P., Parshikov, I.
Zdroj: Chemistry of Heterocyclic Compounds; May1999, Vol. 35 Issue 5, p580-586, 7p
Abstrakt: Optically active 2-(4-hydroxyphenylcarbamoyloxymethyl)-1-methyl-1,2,5,6-tetrahydropyridine is obtained on microbiological transformation of 1-methyl-2-(N-phenyl-carbamoyloxymethyl)-1,2,5,6-tetrahydropyridine with a growing culture of the fungus C. verticillata VKPM F-430. Transformation of 2-(2-phenylethyl)pyridine by a methanoxidating culture of Methylococcus occurs either by hydroxylation of the side chain or conversion of the substrate into N-oxide, depending on the process conditions. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index