| Autor: |
Knutson, Keith, Schiffman, Kathy, Rinn, Kristine, Disis, Mary |
| Zdroj: |
Journal of Mammary Gland Biology & Neoplasia; Oct1999, Vol. 4 Issue 4, p353-365, 13p |
| Abstrakt: |
The application of immunotherapeutic principlesto the treatment and prevention of breast cancer is arelatively new undertaking. Although cytokine infusions,cancer vaccines, and T cell therapy have been extensively studied in solid tumors such asmelanoma and renal cell carcinoma, the therapeuticefficacy of these approaches is not well explored inbreast cancer. The recent definition of tumor-specific immunity in breast cancer patients and theidentification of several breast cancer antigens hasgenerated enthusiasm for the application of immune-basedtherapies to the treatment of breast malignancies. In general, immunotherapies can be consideredeither non-specific, such as a general immunomodulator(e.g., a cytokine), or tumor-specific (e.g., a vaccinethat targets breast cancer tumor antigens). This review describes three major immunotherapeuticstrategies that have the potential to enhance orgenerate an anti-breast cancer T cell immune response:(i) cytokine therapy; (ii) cancer vaccines; and (iii) T cell therapy, and explores how each strategyhas been applied to the treatment of breastcancer. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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