The Evolutionarily Conserved CKAP2 Gene Is Located in Human Region 13q14.3 Often Rearranged in Various Tumors.

Autor: Udina, I., Baranova, A., Kompaniytsev, A., Sulimova, G.
Zdroj: Russian Journal of Genetics; Jan2001, Vol. 37 Issue 1, p105-107, 3p
Abstrakt: The human CKAP2 gene, which is involved in diffuse large B-cell lymphomas, was localized by screening the GeneBridge 4 somatic cell radiation hybrid panel by means of the polymerase chain reaction (PCR). The CKAP2 gene was mapped between the WI-15460 and WI-3673 markers at the boundary between regions 13q14.3 and 13q21.1, at the distance of 14.39 cR (with 4.8 cR per cM) from the WI-5867 framework marker (lod score > 2.26). The human CKAP2 gene displayed high homology to mouse and rat expressed orthologs. A CKAP2-like sequence was found in human chromosome 14 and assumed to be a pseudogene resulting from duplication and subsequent mutations of the CKAP2 gene on chromosome 13. A possible role of the CKAP2 gene in oncogenesis associated with deletions and rearrangements of region 13q14.3–21.1 is discussed. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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