| Autor: |
Barchiesi, F., Schimizzi, A. M., Fothergill, A. W., Scalise, G., Rinaldi, M. G. |
| Zdroj: |
European Journal of Clinical Microbiology & Infectious Diseases; May1999, Vol. 18 Issue 4, p302-304, 3p |
| Abstrakt: |
A broth macrodilution method, performed as recommended by the National Committee for Clinical Laboratory Standards, was used for comparative testing of the new echinocandin antifungal agent MK-0991 and fluconazole against 50 yeast isolates belonging to 12 species of Candida. MK-0991 was shown to be highly effective against both fluconazole-susceptible and -resistant Candida spp., yielding minimum inhibitory concentrations ranging from ≤0.19 to 0.78 μg/ml. Fungicidal activity was exerted at ≤1.5 μg/ml for 73% of the isolates tested. This study suggests that MK-0991 has significant potential for clinical development. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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