Effects of modulation of the cholinergic system activity on the experimental tumor growth and antitumor activity of chlofiden.

Autor: Pous’kov, A., Sharykina, N., Pavlovskaya, G., Karatsuba, T.
Zdroj: Neurophysiology; Mar2000, Vol. 32 Issue 2, p106-110, 5p
Abstrakt: We studied the influence of an anticholinesterase agent, proserine, and an m-cholinoblocker, atropine, on the growth of Pliss lymphosarcoma in rats and on the antitumor activity of a cytotoxic drug, chlofiden. It has been demonstrated that proserine stimulates tumor growth and decreases the antitumor efficacy of chlofiden. Injections of atropine evoked opposite effects: inhibition of the tumor growth and an increase in the, antitumor activity of chlofiden. Possible mechanisms of the above effects are discussed. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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