Calcium dynamics in a bergmann glial cell during metabotropic activation: a simulation study.

Autor:	Kiryushko, D., Korogod, S., Savtchenko, L.
Zdroj:	Neurophysiology; Jul1998, Vol. 30 Issue 4/5, p320-324, 5p
Abstrakt:	A mathematical model of calcium dynamics in a Bergmann cell of the cerebellum is proposed. The model adequately describes the experimentally observed behavior of the prototype, including the shape and time-scale of Ca2+ responses to single and repetitive metabotropic stimuli and the changes of Ca2+ transients caused by inhibition of Ca2+ uptake into the store. By means of the model, the role of calcium pumps in regulating the cytoplasmic Ca2+ concentration is studied. It is found that the store dimension evaluated by stimulation has the order of magnitude of tens of nanometers, and the Ca2+ concentration in the store is about 10 μM. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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