Role of mitochondria in calcium signalling in mammalian sensory neurons.

Autor: Kostyuk, P., Svichar, N., Voitenko, N., Shishkin, V., Kostyuk, E.
Zdroj: Neurophysiology; Jul1998, Vol. 30 Issue 4/5, p191-193, 3p
Abstrakt: Calcium signals evoked at depolarization of the cell membrane and their modifications induced by blocking of accumulation of these ions in the mitochondria and blocking of mitochondrial Na+/Ca2+ exchange were studied in dorsal root ganglion neurons of mice with the use of fluorescent measurements of shifts in the intracellular Ca2+ level. Mitochondria aredemonstrated to be actively involved in formation of these signals by rapid peak absorption of Ca ions from and their subsequent return to the cytosol. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index