Nitric Oxide Participates in the Stimulatory and Neurotoxic Action of Endothelin on Rat Striatal Dopaminergic Neurons.

Autor: Shibaguchi, Hirotomo, Kataoka, Yasufumi, Koizumi, Shuichi, Kohzuma, Masami, Obana, Motoo, Himeno, Akihiko, Yamashita, Kimihiro, Taniyama, Kohtaro
Zdroj: Cellular & Molecular Neurobiology; Oct1997, Vol. 17 Issue 5, p471-481, 11p
Abstrakt: 1. Our method of real-time monitoring of dopamine release from rat striatal slices revealed that endothelin (ET)-3-induced dopamine release was inhibited by NG-methyl-L-arginine (L-NMMA; 1 m M), an inhibitor of nitric oxide (NO) synthase, while NG-methyl-D-arginine (D-NMMA; 1 m M), an inactive isomer of L-NMMA, had no effect. 2. The inhibition of L-NMMA (0.1 m M) became apparent when tissues were pretreated with tetrodotoxin (1 μ M) for 30 min and subsequently exposed to ET-3 (4 μ M). 3. L-NMMA (0.1 and 1 m M) dose dependently protected against ET-3-triggered hypoxic/hypoglycemic impairment of striatal responses to high K+. 4. Thus, NO may work as a promoter in mediation of the stimulatory and neurotoxic action of ET-3 on the striatal dopaminergic system, presumably by interacting with interneurons in the striatum. [ABSTRACT FROM AUTHOR]
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