| Abstrakt: |
Background: Adjustable gastric banding (AGB) is frequently performed to treat morbid obesity. One problem which can occasionally develop after a restrictive procedure is consumption of a high calorie liquid diet, which may prohibit further weight loss. Orlistat, a newly developed intestinal lipase inhibitor, prevents absorption of about one-third of ingested fat. It is unknown whether patients no longer losing weight after AGB, despite further band restriction, may lose weight with addition of orlistat. Methods: 38 patients were selected who had stopped losing weight 3 months before the initiation of the study, 18±6 months (mean±SEM) after laparoscopic AGB. Subjects were divided into 2 groups, matched for age, sex, filling volume of the band and body mass index (BMI) both at the time of surgery and start of the study (18±6 months after AGB). Results: Patients in group A received dietary counseling and orlistat 120 mg TID for 8 months, while patients in group B received only dietary counseling. During the following 8 months of study, subjects in group A lost 8±3 kg in weight, whereas subjects in group B lost 3±2 kg (p<0.01, months 18 vs 26 of study; p<0.03, group A vs B). In 15 patients from group A the study was further extended 9 months, but interestingly, weight remained stable independent of whether orlistat was continued (n=8) or stopped (n=7). 4 subjects were excluded from the extension study because of additional malabsorptive bypass surgery.Subjects taking orlistat encountered only minor GI side-effects. Conclusion: Orlistat appears to be useful when added in patients after AGB who are no longer losing weight, perhaps due to a high-calorie liquid diet rich in fat. [ABSTRACT FROM AUTHOR] |
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