| Autor: |
Abe, Kaori, Takasaki, Yoshinari, Ushiyama, Chifuyu, Asakawa, Junichi, Fukazawa, Toru, Seki, Manami, Hirashima, Mika, Ogaki, Makoto, Hashimoto, Hiroshi |
| Zdroj: |
Journal of Clinical Immunology; Jan1999, Vol. 19 Issue 1, p58-66, 9p |
| Abstrakt: |
CD80 and CD86 were detected in high amounts on circulating T cells in the peripheral blood of some patients with systemic lupus erythematosus (SLE), using flow cytometry and monoclonal antibodies. Patients with other connective tissue diseases did not have a high percentage of T cells expressing CD80 or CD86 in their peripheral blood. CD80 was expressed mainly on CD4 T cells, whereas CD86 was expressed on CD8 T cells, and these two populations were associated with paticular clinical features. These two molecules were expressed on different T-cell populations and might have different roles in the generation and regulation of immune responses. Since high expression of CD86 on T cells was detected much earlier than the appearance of clinical features and a high titer of anti-DNA antibody, it may be a useful parameter for predicting the flare of SLE. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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