Prognostic Value of Flow Cytometric DNA Analysis in Non-Small-Cell Lung Cancer: Rationale of Sequential Processing of Frozen and Paraffin-Embedded Tissue.

Autor: Mugüerza, José M., Díez, Manuel, Torres, Antonio J., López-Asenjo, José A., Picardo, Antonio L., Gómez, Ana, Hernando, Florentino, Cayón, Roberto, Granell, Javier, Balibrea, José L.
Zdroj: World Journal of Surgery; Mar1997, Vol. 21 Issue 3, p323-329, 7p
Abstrakt: p = 0.0006). Including subjects submitted to complete tumor removal (stages I, II, and IIIA) in a multivariate analysis adjusted for TNM stage and histologic type, bearers of aneuploid tumors exhibited a higher risk of relapse (hazard ratio 2.65; CI 95% 1.5–4.66; p = 0.004) or death (hazard ratio 2.17; CI 95% 1.08–4.39; p = 0.032) than patients with diploid tumors. DNA ploidy resulted an independent prognostic factor of survival and tumor relapse in completely resected non-small-cell lung cancer. Sequential analysis of fresh and paraffin-embedded samples can help avoid the bias due to intratumoral DNA content heterogeneity. DNA ploidy could be an useful parameter in any future multifactorial analysis of outcome in such tumors. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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