Bupivacaine Hydrochloride Induces Muscle Fiber Necrosis and Hydroxyl Radical Formation-Dimethyl Sulphoxide Reduces Hydroxyl Radical Formation.

Autor: Wakata, Nobuo, Sugimoto, Hideki, Iguchi, Hiroaki, Nomoto, Nobuatsu, Kinoshita, Masao
Zdroj: Neurochemical Research; Jul2001, Vol. 26 Issue 7, p841-844, 4p
Abstrakt: We induced acute skeletal muscle necrosis in rats using bupivacaine hydrochloride and found that both 2,5- and 2,3-dihydroxybenzoic acid significantly increased in skeletal muscle. A single administration of dimethyl sulphoxide, a free radical scavenger, significantly lowered concentrations of 2,5- and 2,3-dihydroxybenzoic acid. These results suggest that dimethyl sulphoxide is an effective hydroxyl radical scavenger and may be useful in the treatment of myopathy. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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