| Autor: |
Treuth, Mark, Reyes, Guillermo, He, Zuo-Xiang, Cwajg, Eduardo, Mahmarian, John, Verani, Mario, Treuth, M G, Reyes, G A, He, Z X, Cwajg, E, Mahmarian, J J, Verani, M S |
| Předmět: |
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| Zdroj: |
Journal of Nuclear Cardiology; Sep2001, Vol. 8 Issue 5, p548-554, 7p |
| Abstrakt: |
Background: The objectives of this study were 2-fold: (1) to determine the tolerance of adenosine perfusion tomography with the use of an abbreviated (3-minute) infusion in comparison to the standard (6-minute) infusion, and (2) to assess the relative diagnostic accuracy of a 3-minute adenosine infusion in patients referred for arteriography. An abbreviated adenosine infusion may decrease the frequency and duration of side effects and be a more cost-effective alternative.Methods and Results: We prospectively randomized 599 patients undergoing adenosine myocardial perfusion tomography to either a 3-minute or 6-minute adenosine infusion at 140 microg/kg per minute. Among the 599 enrolled patients, 142 subsequently underwent coronary angiography. Patients randomized to the 3-minute adenosine infusion tolerated the procedure better than those randomized to the standard infusion (P <.01). Flushing, headache, neck pain, and atrioventricular block were all significantly less frequent (P <.01) with the abbreviated infusion. Moreover, patients receiving the abbreviated infusion had less hypotension and tachycardia (P <.05). The sensitivity of the test for detection of coronary artery disease was 88% for both the 3- and 6-minute infusions. In patients with abnormal scan results, perfusion defect size was slightly larger in those receiving a 6-minute infusion versus those receiving a 3-minute infusion (P =.05).Conclusions: An abbreviated 3-minute adenosine infusion, in combination with perfusion tomography, has similar sensitivity for detection of coronary artery disease and is better tolerated than the standard 6-minute infusion. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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