| Autor: |
Nanashima, Atsushi, Yamaguchi, Hiroyuki, Sawai, Terumitsu, Yamaguchi, Eiichiro, Kidogawa, Hideo, Matsuo, Seiji, Yasutake, Toru, Tsuji, Takashi, Jibiki, Masaaki, Nakagoe, Tohru, Ayabe, Hiroyoshi, Nanashima, A, Yamaguchi, H, Sawai, T, Yamaguchi, E, Kidogawa, H, Matsuo, S, Yasutake, T, Tsuji, T, Jibiki, M |
| Předmět: |
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| Zdroj: |
Digestive Diseases & Sciences; Aug2001, Vol. 46 Issue 8, p1623-1628, 6p |
| Abstrakt: |
The present study was designed to provide a systemic analysis of prognosis in 62 patients who underwent hepatic resection for colorectal liver metastasis. The analyzed factors included microvessel counts stained by CD34 and expression of two adhesion molecules, E-cadherin and CD44 variant exon 6-(v6) in these tumors. No significant factors related to recurrence were identified and only negative expression of CD44v6 tended to correlate with recurrence (P = 0.075). A short disease-free period to recurrence was noted in patients with high CEA levels (>10 ng/ml) and H2/3 classification. A short surgical margin, H2/3 classification, high microvessel counts (>60/field, x200), and negative expression of CD44v6 and E-cadherin tended to be associated with poor prognosis. A high microvessel count was the most significant prognostic factor by multivariate Cox proportional hazards regression model. Hepatic resection without tumor exposure and a careful follow-up in cases identified with poor prognostic factors are necessary. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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