Sustained viral response is rarely achieved in patients with high viral load of HCV RNA by excessive interferon therapy.

Autor: Shiratori, Yasushi, Kato, Naoya, Yoshida, Haruhiko, Nakata, Ryo, Ihori, Masashi, Imazeki, Fumio, Yokosuka, Osamu, Kawase, Tateo, Katamoto, Tetsuro, Unuma, Tadao, Nakamura, Akira, Ikegami, Fumiaki, Hirota, Katsutaro, Omata, Masao, Shiratori, Y, Kato, N, Yoshida, H, Nakata, R, Ihori, M, Imazeki, F
Zdroj: Digestive Diseases & Sciences; Mar2000, Vol. 45 Issue 3, p565-574, 10p
Abstrakt: Adequate dosing of interferon (IFN) and its cost-effectiveness for sustained virological response were evaluated in relation to viral load and subtype. Prospective analysis of IFN therapy on 326 patients with chronic hepatitis C free from cirrhosis was performed using 9 or 6 million unit (MU) of IFN for six months daily and/or three times a week. Sustained virological response was achieved in 50-94% of patients with < or =2 x 10(4) copies/ml (competitive RT-PCR) or <100 x 10(3) copies/ml (Amplicor monitor) of HCV RNA by 468-1206 MU of IFN, but response was only 0-25% of the patients with > or =2 x 10(5.5) copies/ml (competitive RT-PCR) or >200 x 10(3) copies/ml (Amplicor monitor), even with 468-1206 MU of IFN. A high sustained rate was demonstrated in patients with 100-200 x 10(3) copies/ml of HCV RNA by 901-1206 MU of IFN, in comparison to that with < or =900 MU of IFN. Multivariate analysis showed that IFN dose had a significant value for the efficacy of IFN therapy in patients presenting 100-200 x 10(3) copies/ml of HCV RNA. Cost efficacy analysis indicated that it cost approximately $10,000, $26,000, and $50,000-227,000 for one person-viral eradication in the patients with <100, 100-200, and >200 x 10(3) copies/ml, respectively. High-dose IFN is only cost effective in patients with intermediate viral loads, and IFN therapy could be recommended in patients with <200 x 10(3) copies/ml of HCV RNA. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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