Predictive factors and prevalence of follicular gastritis in adults with peptic ulcer and nonulcer dyspepsia.

Autor:	Ladas, Spiros, Rokkas, Theodore, Georgopoulos, Sotirios, Kitsanta, Panagiota, Liatsos, Christos, Eustathiadou, Paraskevi, Karameris, Andreas, Spiliadi, Charis, Raptis, Sotirios, Ladas, S D, Rokkas, T, Georgopoulos, S, Kitsanta, P, Liatsos, C, Eustathiadou, P, Karameris, A, Spiliadi, C, Raptis, S A
Předmět:	HELICOBACTER disease diagnosis INDIGESTION diagnosis PEPTIC ulcer diagnosis BIOPSY COMPARATIVE studies DEMOGRAPHY DUODENAL ulcers GASTRIC mucosa GASTRITIS HELICOBACTER diseases HELICOBACTER pylori INDIGESTION RESEARCH methodology MEDICAL cooperation PEPTIC ulcer PROGNOSIS PYLORUS RESEARCH EVALUATION research DISEASE prevalence DIAGNOSIS
Zdroj:	Digestive Diseases & Sciences; Jun1999, Vol. 44 Issue 6, p1156-1160, 5p
Abstrakt:	Follicular gastritis is an important histological entity, because it may progress to overt gastric MALT lymphoma. However, there is no universal agreement on whether there is any correlation of follicular gastritis with histological features of the antral mucosa or on the prevalence of follicular gastritis. To shed further light on these issues, we studied antral biopsies obtained from 735 adult patients, who had participated in six consecutive clinical trials. They included 348 patients with duodenal ulcer, 82 with gastric ulcer, and 305 with nonulcer dyspepsia. The Sydney classification system of gastritis was used, using a score of 0-3 to grade degree and activity of inflammation, gland atrophy, intestinal metaplasia, and H. pylori colonization density. Follicular gastritis was defined as prominent lymphoid follicles with no lymphoepithelial lesion. None of the H. pylori-negative patients (N = 159) had follicular gastritis. Among H. pylori-positive patients, 80/340 (23.5%) with duodenal ulcer, 5/77 (6.5%) with gastric ulcer, and 20/159 (12.6%) with nonulcer dyspepsia had follicular gastritis (P < 0.001). Multivariate discriminant analysis selected the following four significant predictor variables for follicular gastritis (Wilks lambda = 0.91, chi2 = 70.6, df = 4, P < 0.001): gastritis sum score, atrophic gastritis, age of the patient, and disease. The prevalence of follicular gastritis was linearly correlated (gamma = 24.55 - 0.98chi, r = -0.62, F1,11 = 6.12, P = 0.03) with the age groups of the 576 H. pylori-positive patients studied. In conclusion, follicular gastritis is highly correlated with H. pylori-caused severe, active gastritis. It is mostly prevalent in the young H. pylori-infected patients with duodenal ulcer. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
Externí odkaz:	Zobrazit plný text záznamu Full text from SpringerLink