| Autor: |
Matsumoto, Kei, Honda, Hirokazu, Shibata, Takanori, Sanada, Daisuke, Wada, Yukihiro, Ashikaga, Eijin, Kuroki, Aki, Kitazawa, Kozo, Akizawa, Tadao |
| Předmět: |
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| Zdroj: |
Nephrology Dialysis Transplantation; Dec2009, Vol. 2 Issue 6, p461-465, 5p, 8 Black and White Photographs, 1 Graph |
| Abstrakt: |
An elderly woman presented with haematuria and proteinuria accompanied by elevated serum myeloperoxidase (MPO)-specific anti-neutrophil cytoplasmic antibodies (MPO-ANCA). A renal biopsy revealed mild mesangial proliferation with fibrocellular crescent formation and a membranous glomerular lesion. Immunofluorescence microscopy using FITC-labelled rabbit anti-human MPO antibodies revealed granular MPO deposition along the glomerular capillary walls (GCW) with a staining profile similar to that of glomerular IgG deposition. The one-year follow-up renal biopsy revealed minimal IgG and undetectable MPO deposition. Both MPO and MPO-ANCA might have been responsible for the IgG immune depositions along the GCW in this patient. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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