| Autor: |
Tokuhara, Takahiro, Adachi, Masashi, Hashida, Hiroki, Ishida, Hisao, Taki, Toshihiko, Higashiyama, Masahiko, Kodama, Ken, Tachibana, Shuichi, Sasaki, Shinjiroh, Miyake, Masayuki |
| Zdroj: |
Japanese Journal of Thoracic & Cardiovascular Surgery; Aug2001, Vol. 49 Issue 8, p489-496, 8p |
| Abstrakt: |
Objectives: Neutral endopeptidase modulates the growth of lung cancer, while aminopeptidase N degrades the extracellular matrix and is involved in cell motility. We studied the metastasis mechanism to detect novel metastasis-associated molecules and to evaluate them for clinical application. Methods: We studied the relationship between the expression of neutral endopeptidase and aminopeptidase N by quantitative reverse transcript-polymerase chain reaction analysis in 132 patients with non-small cell lung cancer undergoing radical surgery from 1991 to 1996. Results: Patients with neutral endopeptidase-positive and aminopeptidase N-negative tumors were defined as group A, those with neutral endopeptidase-positive and aminopeptidase N-positive or neutral endopeptidase-negative and aminopeptidase N-negative tumors as group B, and those with neutral endopeptidase-negative and aminopeptidase N-positive tumors as group C. The 5-year survival of group A patients (92.9%) was significantly better than that of group B patients (64.7%) and much better than that of group C patients (38.2%) (P=0.0011). Neutral endopeptidase and aminopeptidase N thus have statistically significant P in overall survival in Cox regression (P=0.019). Conclusion: Neutral endopeptidase and aminopeptidase N gene expressions are significant indicators of prognosis. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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