Correction of postischemic disturbances in the hemispheres of the brain using precursors of succinyl-CoA biosynthesis.

Autor: Bashun, N., Raduta, E., Balash, Zh., Kirvel, P., Sushko, L., Kanunnikova, N., Moiseenok, A.
Zdroj: Neurochemical Journal; Sep2007, Vol. 1 Issue 3, p249-252, 4p
Abstrakt: We studied the parameters of lipid peroxidation and glutathione systems, energy production, and GABA metabolism in rat brain hemispheres after a 6-h brain ischemia induced by occlusion of both carotid arteries. We showed the development of oxidative stress in the brain and blood plasma, an increase in Krebs cycle enzyme activities, and a decrease in GABA catabolism enzyme activities. Simultaneous injection of panthenol (200 mg/kg, i.p.) and succinate (100 mg/kg, i.p.) led to a successful correction of the above disturbances. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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