Efficacy of intravenous diphenhydramine versus intravenous DHE-45 in the treatment of severe migraine headache.

Autor: Swidan, Sahar, Lake, Alvin, Saper, Joel, Swidan, Sahar Z, Lake, Alvin E 3rd, Saper, Joel R
Zdroj: Current Pain & Headache Reports; Feb2005, Vol. 9 Issue 1, p65-70, 6p
Abstrakt: This study was conducted to compare the efficacy of intravenous diphenhydramine with dihydroergotamine mesylate (DHE-45; Novartis International AG, Switzerland) in the treatment of severe, refractory, migraine headache. A retrospective review was conducted to include eighty randomly chosen patients who were admitted to the Michigan Head Pain & Neurological Institute's inpatient program at Chelsea Community Hospital. Patients had received nine doses of diphenhydramine or nine doses of DHE-45 during a 3-day period. Patients receiving DHE-45 also received metoclopramide (Reglan; AH Robins Company, Inc., Richmond, VA) as prophylaxis for nausea. Demographics, headache diagnosis, psychiatric discharge diagnoses, abortive medications, and adverse events were recorded and assessed. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index