The study of substrate specificity of a new peptide substrate of endothelin-converting enzyme.

Autor: Gureeva, T., Kugaevskaya, E., Pozdnev, V., Prozorovskii, V., Eliseeva, Yu., Solovyeva, N.
Zdroj: Biochemistry (Biokhimiya). Supplemental Series B, Biomedical Chemistry; Sep2007, Vol. 1 Issue 3, p210-215, 6p
Abstrakt: A new hexapeptide CMC-Ala-Gly-Gly-Trp-Phe-Arg was used as a substrate for assay of endothelin-converting (ECE; EC 3.4.24.71) and angiotensin-converting (ACE; EC 3.4.15.1) enzymes and of neutral endopeptidase (NEP; EC 3.4.24.11). The specific inhibitors lisinopril (for ACE) and thiorphan (for NEP) were used for discrimination between activities of these enzymes. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index