Molecular mechanisms of extracellular adenine nucleotides-mediated inhibition of human Cd4+ T lymphocytes activation.

Autor: Duhant, Xavier, Suarez Gonzalez, Nathalie, Schandené, Liliane, Goldman, Michel, Communi, Didier, Boeynaems, Jean-Marie
Zdroj: Purinergic Signalling; Dec2005, Vol. 1 Issue 4, p377-381, 5p
Abstrakt: We have previously reported that ATPγS, a slowly hydrolyzed analog of ATP, inhibits the activation of human CD4+ T lymphocytes by anti-CD3 and anti-CD28 mAb. In this report we have partially characterized the signaling mechanisms involved in this immunosuppressive effect. ATPγS had no inhibitory effect on CD4+ T-cell activation induced by PMA and anti-CD28, indicating that it acts proximally to the TCR. It had no effect on the calcium rise induced by CD3/CD28 stimulation, but inhibited the phosphorylation of three kinases, ERK2, p38 MAPK and PKB, that play a key role in the activation of T cells. The receptor involved in these actions remains unidentified. [ABSTRACT FROM AUTHOR]
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