Permeation mechanism of a two-state potassium channel.

Autor: Wang, Xiangqun, Zhao, Tongjun, Song, Yang, Zhan, Yong
Zdroj: Frontiers of Biology in China; Mar2007, Vol. 2 Issue 1, p108-113, 6p
Abstrakt: A two-state hopping model was proposed to study the permeation of ion channel. The Nernst equation in equilibrium and the Michaelis-Menten relation in steady state were derived from the two-state kinetic model. The current-voltage relationship obtained in the symmetrical solutions case was linear when the applied potential was less than 100 mV, which met Ohm’s law. The conductance-concentration relationship exhibited the saturation property. Moreover, the characteristic time reaching the steady state of the KcsA channel was also discussed. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index